Entrepreneurship plays important role in provision the innovative mode to national economy development. Particularly, small and medium  companies  demonstrates significant innovation potential. The task of innovation transformation in national economy should be implemented through using entrepreneurship, based both on state and private property, as factor driving innovations. The author indicates on policy directions that  would contribute  to innovative entrepreneurial development in Uzbekistan. Particularly, policy measures to stimulate innovative entrepreneurship in Kashkadarya region.